Master student for molecular biology of ovarian cancer

Master Thesis:                       Molecular Biology of Ovarian Cancer

Location:                                Ebene 5Q, AKH

Translational Gynecology Group, Department of Obstetrics and Gynecology, Medical University of Vienna

Duration:                               1 year, start on 1.9.2020

Payment:                               Geringfügige Anstellung (ca. 460€/Monat)

Contact:                                Prof. Dan Cacsire Castillo-Tong

Email:                                     dan.cacsire-castillo@meduniwien.ac.at

Telephone:                            +43-1-40400-78330

Website:                                http://www.octips.eu

 

Background:

Mucinous ovarian cancer is a rare epithelial cancer and is not well investigated. Patients have poor prognosis because there is no specific treatment. Therefore there is urgent need to understand the molecular background of the mucinous cancer and to define therapeutic targets.

 

Objectives:

  • to study molecular mechanisms underlying mucinous ovarian cancer
  • to define genes/pathways as new therapeutic targets
  • to evaluate targetable genes

 

Techniques:

Experimental techniques include genetics, gene expression and protein expression analysis of tumor cells (cell culture, RT-qPCR, Western blotting, cloning, fragment analysis, sequencing), IHC, IF, apoptosis assay, viability/survival assays, senescence assays.

 

Qualification:

Good basic knowledge of molecular biology, strong analytic capacity and commitment, as well as interest in science.

 

Selected relevant publications:

 

  • Kreuzinger C, Decken IV, Wolf A, Gamperl M, Koller J, Karacs J, Pfaffinger S, Bartl T, Reinthaller A, Grimm C, Singer CF, Braicu EI, Cunnea P, Gourley C, Smeets D, Boeckx B, Lambrechts D, Perco P, Horvat R, Berns EMJJ, Castillo-Tong DC. Patient-derived cell line models revealed therapeutic targets and molecular mechanisms underlying disease progression of high grade serous ovarian cancer. Cancer Lett. 10;459:1-12, 2019. doi: 10.1016/j.canlet.2019.05.032.

 

  • Kreuzinger C, Geroldinger A, Smeets D, Braicu EI, Sehouli J, Koller J, Wolf A, Darb-Esfahani S, Jöhrens K, Vergote I, Vanderstichele A, Boeckx B, Lambrechts D, Gabra H, Wisman GBA, Trillsch F, Heinze G, Horvat R, Polterauer S, Berns EMJJ, Theillet CG, Cacsire Castillo-Tong D. A complex network of tumor microenvironment in human high grade serous ovarian cancer. Clin Cancer Res. 2017 Oct 2. pii: clincanres.1159.2017. doi: 10.1158/1078-0432.CCR-17-1159. [Epub ahead of print]

 

  • Kreuzinger C, Gamperl M, Wolf A, Heinze G, Geroldinger A, Lambrechts D, Boeckx B, Smeets D, Horvat R, Aust S, Hamilton G, Zeillinger R, Cacsire Castillo-Tong D. Molecular characterization of 7 new established cell lines from high grade serous ovarian cancer. Cancer Lett. 362:218-28, 2015. doi: 10.1016/j.canlet.2015.03.040.
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